I shall develop a Slicer Module so I need the whole package running everywhere, so yeah I am ready to accept challenges.
If you need PythonQT that is not available in the nightly, you will need to take care of a lot of packaging both for the application and the modules. Before you spend too much time on this, I would check if make package
in Slicer-build
directory generates usable binaries for the platforms you need to support. I don’t know if anyone tested that.