There have been lots of work in Slicer for pedicle screw insertion planning and guidance (by augmented reality using HoloLens, ultrasound guidance, etc.).
There is a complete open-source implementation for HoloLens/Slicer see github repository here (and related paper):
No need to mess with Blender, but the scene is generated in Slicer and sent to the HoloLens directly from there in real-time. Rendering in this repository is done via Unity, but recent Slicer versions can render directly to any AR/VR headset (via OpenXR API). So, there is no need to use multiple applications and programming languages (everything can be implemented in a single Slicer application, in Python or C++).
What AR headset are you planning to use now that the HoloLens is dead? Video passthrough in Meta Quest 3?