# DCE analysis - Fitted signal curve does not make sense

**URL:** https://discourse.slicer.org/t/dce-analysis-fitted-signal-curve-does-not-make-sense/3403
**Category:** Support
**Tags:** dce
**Created:** [June 26, 2018, 9:02pm UTC](https://discourse.slicer.org/t/dce-analysis-fitted-signal-curve-does-not-make-sense/3403 "2018-06-26T21:02:24Z")
**Posts on this page:** 4
**Page:** 1

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### Author: ![bmb777](https://avatars.discourse-cdn.com/v4/letter/b/eb8c5e/32.png) [@bmb777](https://discourse.slicer.org/u/bmb777)
#### Post date: [June 26, 2018, 9:02pm UTC](https://discourse.slicer.org/t/dce-analysis-fitted-signal-curve-does-not-make-sense/3403/1 "2018-06-26T21:02:24Z")

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Is the issue with the Output Fitted Data 4D a common issue? I believe I am having the same difficulty with viewing the fitted results as what is shown above and wonder if there is a way to fix/work around this. Specifically the output 4D data shows a flat baseline for all the voxels similar to what Sharon showed in post 25.

 ![Output%20fitted](https://us1.discourse-cdn.com/flex002/uploads/slicer/original/3X/9/4/9466df47f0ddfba7acc8fb05d0c1579119764c36.jpeg)

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### Author: ![fedorov](https://sea2.discourse-cdn.com/flex002/user_avatar/discourse.slicer.org/fedorov/32/14_2.png) [@fedorov](https://discourse.slicer.org/u/fedorov)
#### Post date: [July 2, 2018, 1:35pm UTC](https://discourse.slicer.org/t/dce-analysis-fitted-signal-curve-does-not-make-sense/3403/2 "2018-07-02T13:35:17Z")

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@bmb777 no, it should not be a common issue. This needs to be investigated, but I am strapped on time right now, and have no one to delegate.

Could you possibly [submit an issue to PkModeling](https://github.com/QIICR/PkModeling/issues/new) and include a pointer to a dataset that allows to reproduce this problem?

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### Author: ![bmb777](https://avatars.discourse-cdn.com/v4/letter/b/eb8c5e/32.png) [@bmb777](https://discourse.slicer.org/u/bmb777)
#### Post date: [July 3, 2018, 3:39pm UTC](https://discourse.slicer.org/t/dce-analysis-fitted-signal-curve-does-not-make-sense/3403/3 "2018-07-03T15:39:58Z")

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@fedorov  
edit 2: The issue was cause by me prescribing the AIF with units of milliseconds rather than seconds. Changing this corrected the issue.

 ![Capture3](https://us1.discourse-cdn.com/flex002/uploads/slicer/original/3X/1/5/155dffcff7a02921af0c75286e2c9534a753a76e.jpeg)

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### Author: ![fedorov](https://sea2.discourse-cdn.com/flex002/user_avatar/discourse.slicer.org/fedorov/32/14_2.png) [@fedorov](https://discourse.slicer.org/u/fedorov)
#### Post date: [July 6, 2018, 3:05pm UTC](https://discourse.slicer.org/t/dce-analysis-fitted-signal-curve-does-not-make-sense/3403/4 "2018-07-06T15:05:27Z")

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@bmb777 I am glad you resolved it, and I really appreciate that you took the time to post the resolution back to the forum! 👍