# General Registration (BRAINS) descriptors or features used to make Affine Registration (12 DOF)

**URL:** <https://discourse.slicer.org/t/general-registration-brains-descriptors-or-features-used-to-make-affine-registration-12-dof/1331>\
**Category:** Support\
**Tags:** registration, brainsfit, brain\
**Created:** [October 31, 2017, 2:53pm UTC](https://discourse.slicer.org/t/general-registration-brains-descriptors-or-features-used-to-make-affine-registration-12-dof/1331 "2017-10-31T14:53:04Z")\
**Posts on this page:** 3\
**Page:** 1

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**Author:** ![Mohammed\_EL\_ADOUI](https://avatars.discourse-cdn.com/v4/letter/m/6bbea6/32.png) [@Mohammed\_EL\_ADOUI](https://discourse.slicer.org/u/Mohammed_EL_ADOUI)\
**Post date:** [October 31, 2017, 2:53pm UTC](https://discourse.slicer.org/t/general-registration-brains-descriptors-or-features-used-to-make-affine-registration-12-dof/1331/1 "2017-10-31T14:53:04Z")

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Operating system: Linux  
Slicer version: 4.5.0

Recently, I used 3D slicer to make co-registration between breast tumor images (MRI). I used the General Registration (BRAINS), in which I used the linear transform initialized with “useMomentsAlign”. Then ,I used the flowing registration phases in order : Rigid(6 ODF), Rigid+scale(7 ODF) and Affine(12 DOF). As results, I have a good registration with the transformation file (.h5) containing the 12 transformations. My question is about the descriptors/features used in this registration, I means what is the operations used to found the 12 unknown variables (12 DOF). I imagine that a comparison between the two inputs images descriptors are made but which features exactly? (is it the shape, intensities …?)

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**Author:** ![ihnorton](https://sea2.discourse-cdn.com/flex002/user_avatar/discourse.slicer.org/ihnorton/32/9_2.png) [@ihnorton](https://discourse.slicer.org/u/ihnorton)\
**Post date:** [October 31, 2017, 2:56pm UTC](https://discourse.slicer.org/t/general-registration-brains-descriptors-or-features-used-to-make-affine-registration-12-dof/1331/2 "2017-10-31T14:56:22Z")

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(please only post once – the first post must be approved, and usually someone will see it within 1-2 hours)

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**Author:** ![pieper](https://sea2.discourse-cdn.com/flex002/user_avatar/discourse.slicer.org/pieper/32/8_2.png) [@pieper](https://discourse.slicer.org/u/pieper)\
**Post date:** [October 31, 2017, 3:25pm UTC](https://discourse.slicer.org/t/general-registration-brains-descriptors-or-features-used-to-make-affine-registration-12-dof/1331/3 "2017-10-31T15:25:35Z")

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The module documentation page has lots of information on that:

[https://www.slicer.org/wiki/Documentation/4.8/Modules/BRAINSFit](https://www.slicer.org/wiki/Documentation/4.8/Modules/BRAINSFit)