# Radiomics Image normalization

**URL:** <https://discourse.slicer.org/t/radiomics-image-normalization/14710>\
**Category:** Support\
**Created:** [November 20, 2020, 2:30pm UTC](https://discourse.slicer.org/t/radiomics-image-normalization/14710 "2020-11-20T14:30:19Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![sarvpriya1985](https://sea2.discourse-cdn.com/flex002/user_avatar/discourse.slicer.org/sarvpriya1985/32/4094_2.png) [@sarvpriya1985](https://discourse.slicer.org/u/sarvpriya1985)\
**Post date:** [November 20, 2020, 2:30pm UTC](https://discourse.slicer.org/t/radiomics-image-normalization/14710/1 "2020-11-20T14:30:19Z")

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Hi everyone,

I would like to ask about process of doing image normalization for radionics. I have multi sequence MRI brain images. I would like your opinion on should I first normalize the entire image or I should first segment my ROI and then normalize the ROI only. Is there going to be any significant difference between those two approaches and which is considered optimal.

Thanks  
Sarv