# Registration Problem: Brain T2WI to T1WI

**URL:** <https://discourse.slicer.org/t/registration-problem-brain-t2wi-to-t1wi/35922>\
**Category:** Support\
**Tags:** registration\
**Created:** [May 5, 2024, 12:33am UTC](https://discourse.slicer.org/t/registration-problem-brain-t2wi-to-t1wi/35922 "2024-05-05T00:33:17Z")\
**Posts on this page:** 4\
**Page:** 1

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**Author:** ![lotus](https://avatars.discourse-cdn.com/v4/letter/l/0ea827/32.png) [@lotus](https://discourse.slicer.org/u/lotus)\
**Post date:** [May 5, 2024, 12:33am UTC](https://discourse.slicer.org/t/registration-problem-brain-t2wi-to-t1wi/35922/1 "2024-05-05T00:33:17Z")

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I have a registration problem, I want to register brain T2WI to T1WI, but the matrix and resolution of the two images are inconsistent, how should I deal with it, thank you

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**Author:** ![pieper](https://sea2.discourse-cdn.com/flex002/user_avatar/discourse.slicer.org/pieper/32/8_2.png) [@pieper](https://discourse.slicer.org/u/pieper)\
**Post date:** [May 5, 2024, 12:16pm UTC](https://discourse.slicer.org/t/registration-problem-brain-t2wi-to-t1wi/35922/2 "2024-05-05T12:16:08Z")

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> [@lotus](#):
>
> matrix and resolution of the two images are inconsistent

That shouldn’t matter - if it’s the same subject then the normal registration tools should work very reliably.

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**Author:** ![lotus](https://avatars.discourse-cdn.com/v4/letter/l/0ea827/32.png) [@lotus](https://discourse.slicer.org/u/lotus)\
**Post date:** [May 25, 2024, 7:44am UTC](https://discourse.slicer.org/t/registration-problem-brain-t2wi-to-t1wi/35922/3 "2024-05-25T07:44:00Z")

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More specifically, T2WI is a 2d image and T1WI is a 3d image. After many attempts, the registration effect is not satisfactory. I observed that on 2D T2WI images, the sagittal and coronal positions seemed to be compressed and could not be clearly displayed. How should this situation be handled

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**Author:** ![LeidyMoraV](https://sea2.discourse-cdn.com/flex002/user_avatar/discourse.slicer.org/leidymorav/32/70144_2.png) [@LeidyMoraV](https://discourse.slicer.org/u/LeidyMoraV)\
**Post date:** [May 25, 2024, 4:00pm UTC](https://discourse.slicer.org/t/registration-problem-brain-t2wi-to-t1wi/35922/4 "2024-05-25T16:00:18Z")

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Try with landmark registration