Abdominal CT registration using Elastix

Thank you. If I’m understanding right I could try two things:

  1. crop an ROI, register this with a fixed volume and then use the transform to register the non-cropped image in ‘Transform’.
  2. create or specify a mask by for example using ‘Foreground Masking (BRAINS)’ and apply this mask in Elastix as mask. Or are there any other options to create a mask for registration?