Does Slicer support this kind of PET-CT registration?

[ihnorton (Isaiah Norton)]

Generally speaking, yes. CT-CT should work very well; PET-CT can be a bit harder because PET is typically low resolution and has poorly defined skull. Please see the Registration Case Library, especially 8, 14, and 20.

I think most of the examples in the case library use other tools, but Elastix is now available as an extension and may be a good option to try first:

Elastix registration toolbox is now available in Slicer

Elastix is a very powerful registration toolbox with lots of advantages over stock ITK registration tools - it has many more metrics, transformation methods, constraints, optimizers, and it comes with a large registration parameter set database, which contains optimized settings for a wide range of registration tasks. This toolbox is now available in Slicer, through the SlicerElastix extension, in the latest nightly builds. Even the default settings work really well for simple (same patient, s…