How does HD BET work?

I am writing an essay about a brain segmentation I did and I was wondering if some of you could explain me how does the HD Brain Extraction Tool actually work. By reading on the github page, it seems to me that it works statistically, but maybe you can tell me more about it.

Here is the associated paper that you can read the details

In particular, the supplemental document hat is available for this paper provides more detailed information about the underlying ANN network design etc

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