i want to know if it is possible to do image registration on images of different anatomical orientations

[muratmaga]

Please see this thread about manually aligning and resampling the images to a custom orientation:

How to properly use the segment editor with transformed volumes

Thank you, this sample image was helpful. A simple workflow can be: Select volume The module switches to four-up view and enables interactive slice intersections Rotate slice intersections using drag-and-drop to show axial slice in red and coronal slice in green Click “Align” button The module rotates volume to make the slice planes aligned with anatomical axes. The result is that the volume is oriented correctly in physical space, except there may be flips. Click Flip LR, Flip AP, or F…

There many registration tools in Slicer (Brains, ANTs, Elastix) however, they all will require the starting orientations to be approximately similar.