Neither of the two new view orientation options (patient right is screen left (default)/patient right is screen right) match the scrolling behavior of the previous unconfigurable Slicer behavior.
Thanks for the report and tracking down the likely issue. Let’s see what @lassoan thinks and we can make the appropriate fix. I would vote for restoring the old behavior by default.
The old default SliceToRAS coordinate systems were left-handed for no particular reason. We use right-handed coordinate system everywhere else. Using left-handed slice coordinate system turns models inside out and can introduce other small inconsistencies when we transform objects to the slice plane, so I would consider it as an undesirable behavior.
Comparison of left/right-handedness of coordinate systems between preview and stable release
Using Slicer-4.11.20110226: two left handed, one right-handed
The old behavior of the arrow keys in the slice views was that right arrow always went the in the RAS directions (right arrow on a sagittal went to patient right, right arrow on coronal went anterior, right arrow on an an axial went superior). Now axial and sagittal are reversed from that, which probably is something everyone could get used to, but it seem illogical to me.