I am working on TA to study changes in a longitudinal study.
I am doing 2 step registration process - 1. affine from A to B and later Bspline using this affine as a linear transform.
However, I have following queries
- Is it necessary to select histogram matching for TA (I have already performed N4 bias correction)
- If I have to select this option, shall I choose this during affine transformation or non-rigid part of registration?
Please note brain scans B/C etc are distorted post surgery.
- And does baseline scan (A) need any registration ? as it will be used as a template and also control?
Thanks in advance.