I am working on a 2 groups of patients with different therapies in brain cancer. I carried out T2 MRI texture analysis for different ROI. In selected 10 features for heterogeneity (uniformity, TE, entropy, variance, kurtosis, cluster shade, Difference variance, difference entropy, correlation etc), I found only Total Energy ( TE) to be showing significant difference between two groups and no other feature shows significant difference when these groups are compares.
Besides in other larger group I found TE to the only consistent feature found to be correlated with the dose while others do not show this consistent findings.
Can someone help me to interpret these results.
It would be interesting to also assess volume and other shape features in this case. TE is known to be heavily dependent on volume.
Thank you for your reply. Its a 2D MRI slice with 2D circular ROI of same fixed diameter. All other factors are almost matched.I am trying to understand what can TE represent?
In some other areas, other features show difference too but overall TE is the clear winner with maximum association.