Registration Problem: Brain T2WI to T1WI

I have a registration problem, I want to register brain T2WI to T1WI, but the matrix and resolution of the two images are inconsistent, how should I deal with it, thank you

That shouldn’t matter - if it’s the same subject then the normal registration tools should work very reliably.

More specifically, T2WI is a 2d image and T1WI is a 3d image. After many attempts, the registration effect is not satisfactory. I observed that on 2D T2WI images, the sagittal and coronal positions seemed to be compressed and could not be clearly displayed. How should this situation be handled

Try with landmark registration