@sscotti Are you required to use DICOM TLS inside the trusted hospital network? It may make sense, I just don’t see this happening in the hospitals that we have been working with. I don’t think this question has ever come up in Slicer Forum discussions either.
That said, as @pieper wrote above, DCMTK seems to support DICOM TLS. Since we already use OpenSSL in Slicer, it would be mainly GUI work to allow the user to specify the extra connection information and pass it to DCMTK. If you are interested in working on it, we can help you getting started and with answering any specific questions.