This error has been reported to happen for resource-intensive applications, such as games, and seems to be caused by faulty graphics driver operating system configuration.
- https://answers.microsoft.com/en-us/windows/forum/windows_10-hardware/application-has-been-blocked-from-accessing/ad02b3e9-0785-44c7-a916-40d05b0a246e
- https://steamcommunity.com/app/730/discussions/0/38596747815376419/
- http://www.tomshardware.com/answers/id-2834294/program-denied-access-graphics-hardware.html
Based on my experience, NVidia Quadro users often run into strange driver/compatibility issues. Quadro GPUs are tested very thoroughly for a small set of applications (certain CAD software, etc.) but probably not much for anything else. If you only use NVidia Quadro certified applications then go with a Quadro, otherwise I would recommend to use GeForce GPUs instead - it is less expensive and more robust.