Hello all,
I have a problem opening the ALPACA extension, with the stable version of 3D slicer 5.10.0 .
The error code says, it can’t find a certain file. I should have installed all additional extensions to run the extension. I reinstalled the extension again, without solving the problem. On the version 5.8.1 ALPACA works on my device.
Thank you for your help and advice.
Hi!
The issue is a missing itk Python package in Slicer 5.10.0’s environment. Open the Python Interactor in Slicer and run:
slicer.util.pip_install(‘itk’)
Then restart Slicer and try opening ALPACA again. That should fix it!
I did run the command and this was the reply. Nothing changed regarding the problem.
muratmaga
(Murat Maga)
February 20, 2026, 4:43pm
4
It appears your slicer 5.10 installation is problematic for some reason. E.g., the real issue is the first error (Application Does Not exist).
I suggest freshly installing it to a new place (like your desktop), install SlicerMorph and retry.
Ok, I did that and got the exact same error as the first time.
I did save it on the desktop as you suggested.
muratmaga
(Murat Maga)
February 20, 2026, 7:15pm
6
what happens when you do the pip_install(“itk”)
The second screenshot shows just that or did I do something wrong? It says the Application does not exist.
muratmaga
(Murat Maga)
February 23, 2026, 5:07pm
8
I think there is something weird going on with your installation, though don’t know why. I am going to assume you will get the same problem if you try to pip install another package, like pip_install(“scipy”)
Yes, the same error occurs. The Application does not exist.
muratmaga
(Murat Maga)
February 23, 2026, 5:37pm
10
I don’t why. I Just did a fresh install of a 5.10 package I downloaded from download.slicer.org , installed SlicerMorph and run ALPACA on my windows computer and everything worked as expected. I wonder if you have antivirus or centrally managed something that removes files. All I can say maybe try with a different computer
Python 3.12.10 (main, Feb 12 2026, 15:11:32) [MSC v.1944 64 bit (AMD64)] on win32
>>>
[Qt] libpng warning: iCCP: profile 'ICC Profile': 'CMYK': invalid ICC profile color space
[Qt] libpng warning: iCCP: known incorrect sRGB profile
Collecting mistune
Downloading mistune-3.2.0-py3-none-any.whl.metadata (1.9 kB)
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Successfully installed mistune-3.2.0
Collecting itk~=5.4.0
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Installing collected packages: itk-core, itk-numerics, itk-io, itk-filtering, itk-segmentation, itk-registration, itk
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Requirement already satisfied: itk-io==5.4.5 in c:\users\amaga\desktop\3d slicer 5.10.0\lib\python\lib\site-packages (from itk==5.4.*->itk-fpfh~=0.2.0) (5.4.5)
Requirement already satisfied: itk-filtering==5.4.5 in c:\users\amaga\desktop\3d slicer 5.10.0\lib\python\lib\site-packages (from itk==5.4.*->itk-fpfh~=0.2.0) (5.4.5)
Requirement already satisfied: itk-registration==5.4.5 in c:\users\amaga\desktop\3d slicer 5.10.0\lib\python\lib\site-packages (from itk==5.4.*->itk-fpfh~=0.2.0) (5.4.5)
Requirement already satisfied: itk-segmentation==5.4.5 in c:\users\amaga\desktop\3d slicer 5.10.0\lib\python\lib\site-packages (from itk==5.4.*->itk-fpfh~=0.2.0) (5.4.5)
Requirement already satisfied: numpy in c:\users\amaga\desktop\3d slicer 5.10.0\lib\python\lib\site-packages (from itk==5.4.*->itk-fpfh~=0.2.0) (2.0.2)
Downloading itk_fpfh-0.2.1-cp311-abi3-win_amd64.whl (459 kB)
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Requirement already satisfied: itk-numerics==5.4.5 in c:\users\amaga\desktop\3d slicer 5.10.0\lib\python\lib\site-packages (from itk==5.4.*->itk-ransac~=0.2.1) (5.4.5)
Requirement already satisfied: itk-io==5.4.5 in c:\users\amaga\desktop\3d slicer 5.10.0\lib\python\lib\site-packages (from itk==5.4.*->itk-ransac~=0.2.1) (5.4.5)
Requirement already satisfied: itk-filtering==5.4.5 in c:\users\amaga\desktop\3d slicer 5.10.0\lib\python\lib\site-packages (from itk==5.4.*->itk-ransac~=0.2.1) (5.4.5)
Requirement already satisfied: itk-registration==5.4.5 in c:\users\amaga\desktop\3d slicer 5.10.0\lib\python\lib\site-packages (from itk==5.4.*->itk-ransac~=0.2.1) (5.4.5)
Requirement already satisfied: itk-segmentation==5.4.5 in c:\users\amaga\desktop\3d slicer 5.10.0\lib\python\lib\site-packages (from itk==5.4.*->itk-ransac~=0.2.1) (5.4.5)
Requirement already satisfied: numpy in c:\users\amaga\desktop\3d slicer 5.10.0\lib\python\lib\site-packages (from itk==5.4.*->itk-ransac~=0.2.1) (2.0.2)
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Installing collected packages: itk-ransac
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You were right my antivirus was the cause of the problem now everything works fine.
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