Combining Multiple DICOM Volumes into a Single High-Quality Volume for Segmentation

Hello everyone,

I am working on a DICOM dataset with three volumes (axial, sagittal, and coronal) of a brain MRI study. Each volume is clear and high-quality for its respective orientation (e.g., axial cuts in the axial volume), but the other orientations appear very pixelated.

My goal is to create a single merged volume that combines the high-quality slices from each orientation (axial, sagittal, and coronal) into one coherent dataset that I can use for segmentation and further analysis.

I have attempted the following:

  1. Volume Registration: Using the General Registration (BRAINS) module, I aligned the volumes. However, the output remains pixelated in non-primary orientations.
  2. Resampling: Adjusting B-Spline grid size, percentage of samples, and interpolation mode. The results are still not satisfactory.
  3. Merging Volumes: I looked for ways to combine the clear slices from each volume into a single node but couldn’t find an effective solution.

Here are my questions:

  1. Is there a recommended method to merge slices from different volumes while retaining their original quality?
  2. Are there specific settings I should tweak in the registration or resampling process to improve the results?
  3. Should I use a different approach entirely to achieve my goal?

Thank you for your guidance!


Short answer is that it’s not really doable to combine the multiple series into one higher res volume. But if your goal is to segment the tumor you should look into the BraTS models in Auto3DSeg.

More info on combining series: