Error with calculation image difference in Registration QA module using ROI

Slicer version: 4.13.0 and Slicer 4.11.20200930

Hello everyone,

I want to calculate the image difference between the fixed and warped image, after registration, using a specified ROI. I manually created the ROI, but after assign it the role as ROI in Registration Quality Assurance module, there was a shift and the result of the image difference was wrong.

The error occurred in both 3D Slicer versions.

Thanks for the help.