This is just a warning, you don’t need to worry about it. Is there any other problem? What are you trying to do? What do you expect to happen? What happens instead?
which is default grid size, the application give me results without error. When I use the output of bspline from this grid size and apply it on preop MRI, It is not transformed as expected. The results of transform of bspline on preop should result in close results to intraop mri, but i am not getting it.
Second, if I am increasing or decreasing the grid size it results into error.
Without any images and more informative error messages, it’s hard to tell what should be changed. Typically, “General registration (BRAINS)” module is a bit hard to use because you need to manually tune its parameters. You can find description of all parameters here and there are many examples in the Registration Case Library.
I find “General registration (Elastix)” module (provided by SlicerElastix extension) much easier to use, as the default rigid and bspline deformable presets usually work well (no manual parameter tuning is needed).