How can I configure Slicer to open automatically with my preferred settings for the View Controllers module?

[lassoan (Andras Lasso)]

@DIV

Each Segmentation must be associated with a Volume (providing radiodensity) and a Geometry (providing the grid) at any given moment.

You only need a volume for editing segmentations. Some Segment Editor effects would not need it, but it was easier to just make this a prerequisite for segmentation.

@DIV

The Geometry of the Segmentation can be identical to the geometry of its Master Volume, or it can be a modified version of that ( e.g . forced to be isotropic), or it can be based on a totally different source (possibly a Volume, with prespecified geometry, or perhaps a ROI with a customisable user-specified geometry).

Correct.

@DIV

From time to time the Volume and/or Geometry on which a Segmentation is based can be changed.

Correct. Since image resampling is a lossy operation, and it is particularly bad for binary images, it is better to avoid changing geometry of existing segmentations. However, a one-time cropping and resampling to isotropic spacing before starting segmentation is usually beneficial.