Usually when meshes appear with unexpected orientation it is due to difference in coordinate system (LPS/RAS). If you are loading a mesh file (.vtk, .ply, .stl, … file ) and the coordinate system is not specified in the file header then Slicer assumes DICOM convention (LPS), but you can choose RAS after you select the file (in “Add data” window click on “Show options” in the top-right corner).