Image dimensions, image spacing and segmentation size

Hello everyone
I have question, I have several CBCTs for same patient taken in different time points, these CBCTs are in different image dimensions and image spacing, and i want to measure and compare the size of a certain segmented structure among these time points using Segment Statistics module .

Dose the difference in image dimensions and image spacing affect the segmentations statistics between different time points?

will a segmentation with larger voxel spacing be computed larger in terms of volume (number of voxels) compared to one with smaller spacing, even if they delineate the same structure?