Hats off to Alex Ling, Nino Chiocca, Nathalie Agar, and the team at Brigham and Women’s neurosurgery for their excellent work and stunning cover image. Alex provided the explanation below about how he used Slicer to make this image.
https://www.science.org/doi/10.1126/scitranslmed.adv2881
The solid red cylinders represent biopsy needle core volumes from the tissue collected across the 6 trial surgeries for patient DFCI2 from the manuscript. The semi-transparent red volume represents enhancing tumor volume on trial day 118, and the semi-transparent yellow volume represents necrotic tumor core (as assessed by MRI). The green spheres represent sites of CAN-3110 injection across the 6 trial surgeries for DFCI2. The multicolor brain volume is a rendering of a T1 post-contrast MRI scan (DFCI2 day 118) in 3D Slicer version 5.1.0 with the DTI-FA-Brain color scheme preset applied. The colors represent different MRI intensity ranges, but these were done primarily for artistic purposes and shouldn’t be construed to precisely correlate to specific brain structures.