Neuronavigation using Kinect sensor

I am trying to implement Neuronavigation using Kinect Hardware , till now i have built the plus-server to recognise the Kinect hardware and i get both RGB and Depth streams and RGB-D (Fused streams) as well , I am wondering which should i use for Neuronavigation?

1.RGB with ArUco markers

2.Depth with Spherical Fiducial Markers

3.RGB-D streams? or should i Use PCL streams?

Thank you in advance