If the DWI was loaded as a diffusion volume you’ll need to extract a scalar from it. E.g.estimate the tensor and use the baseline image or create a scalar map like FA (you can do these steps with SlicerDMRI).
Check the Volume type field of the Volume Information tab of the Volumes module. It should be Scalar to work with the registration tools. If not you need to convert it, e.g. with the Vector to Scalar Volume module, depending on the type.
That means your DWI was loaded as a MultiVolume and you can either use the MultiVolume modules to extract a frame from it for registration. Or you can convert it to a Sequence and use that newer infrastructure.