Scanner Comparision

Dear Community,
I am new to pyradiomics and currently try to compare different scanners to each other. There is a difference in shape features even though the organs are about the same size in real world. (The nifti images also have a different size (like 22,351,483 vs 27,702,966 in the other scanner))
How can I take these differences into account when calculating features and does the size have an influence on first order and second order features? Just resampling the spacing unfortunately doesn’t change anything.

Many thanks in advance