Osteolytic lesions due to polyethylene wear

Dear Slicing community :),
Does someone knows how to measure volume of osteolytic lesions due to polyethylene wear of THR, both on acetabular(pelvic) and femoral side?

I guess you would need to have the diagnostics images (MRI, CT, etc), then segment the structures of interest and the use ‘Segment Comparision’ to compare both volumes.