I know you can run Slicer on a Surface Tablet and a Surface Studio, but has anyone tried on a Surface Hub 2S?
It should work without any problems - the same way as on any Windows 10 PC with a large display. You can probably navigate the views (rotate, zoom, pan, twist) using multi-touch and use the pen for precise drawing.
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Our hospital network just got a few of these and apparently they installed Windows 10 Team, which is a simplified version of Windows 10. Thankfully, there are ways of migrating the device to the full version of Windows 10 Pro. Otherwise, I may try using a portable version of Slicer!
Let us know how it works. Take a few videos if you can.