Wondering if I can create segmentation label from imported STL object?

[lassoan (Andras Lasso)]

Probably the STL file is defined in LPS coordinate system. Slicer assumes it is in RAS. Try transforming the model from LPS to RAS coordinate system by applying a transform as described here:

DICOM and VTK file orientation Issue

Most common issue is LPS/RAS coordinate system mismatch. So, may try to convert your data from LPS to RAS coordinate system by transforming it using Transforms module by a matrix that has [-1,-1,1,1] in the diagonal: [image]