Calculating difference in dose between two CT scans

I’m doing a project which requires me to analyse the difference in dose between two identical CT scans reconstructed with different algorithms. Is there any way for me to do this with slicer and slicerRT?

We need more information. You don’t mention radiotherapy anywhere, so first question would be CT dose or RT dose? Please elaborate as much as possible, what kind of data do you have, what kind of comparison you want to do… Thanks.