Correlation analysis of shape parameters with a continuous variable

I am new to shape analysis in general and I want to correlate a continuous pathological variable ( for example % of necrosis) with shape of a lesion ( I assume spherical topology).

I assume Covariate Significance testing will the module that I use - but I am unsure about how to proceed.
Further I am unsure how to interpret the results that come up in the Population viewer.

Thanks in advance