I have numerous files that fall into either of the categories above: the image is fully highlighted during the thresholding process and creating a segmentation successfully, or it is only highlighting the edges and not creating a segmentation. How can I fix the second category to create segmentations?
Might be related to the extremely high (128K) max intensity value in your second datasets. Most DICOM datasets are 16 bit and goes up to 65K. You may want to rescale your intensity ranges for this dataset (using simple filters) and try anew.