Threshold range in 3D Slicer is [0, 99]

Task manager shows that you are running out of memory. The error message tells the same. Configure 50-100GB more virtual memory or crop and/or downsanple the image before starting segmentation.

The flag allows you to indicate for yourself that you a segment is correct and complete. It is essential when you have hundreds of segments. See details here: New feature: Search and filter in segments table